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Archive for the ‘a urology in gainesville georgia’ Category

Penelope on Jibjab

Don’t monkey around with prostate cancer!

as we grow older...the beauty steals inward... emerson

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every saint has a past….every sinner a future w buffett

Podcast on “Waiting on the damn prostate biopsy results.” You’ve been there haven’t you?

 

 

 

 

 

 

 

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the only place you'll find success before work is in the dictionary

For years urologists have been aware of the “upgrading” of the Gleason’s score when comparing the biopsy report with the final pathology report. The tricky thing here is that  the urologist and the “surveillance minded” patient are making decisions about surveillance on limited information, i.e. the biopsy report. ( Think of twelve cores about twice the width of a hair taken from a lemon which may or may not give you the true indication of the nature of your prostate cancer.) What is nice about the below and other studies is that of the people who progressed, no harm seems to be done with the delay in treatment. (Putting off the inevitable comes to mind for some of these patients.) As I have said it takes a certain mindset to agree to pursue surveillance. One is living with the known diagnosis of cancer, and is subjected usually to twice a year PSA’s and a yearly biopsy. If you are that percent that delayed treatment for a year or so….would that be worth it to you. As my mother said….”to each his own.”  By the way… I encourage surveillance for the patient that meets the criteria and has the mind for it.

Gleason grade often changes during active prostate surveillance
Publish date: Jun 1, 2011
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Epidemiology

Last Updated: 2011-06-01 16:04:17 -0400 (Reuters Health)

By Dave Levitan

NEW YORK (Reuters Health) – Changes in Gleason score are common during active surveillance for prostate cancer, a new paper says.

About 25% of such men will have subsequent negative biopsies and about 35% will have an upgrade, said lead author Dr. Sima Porten of the University of California, San Francisco, in an e-mail to Reuters Health.

Until now, not much was known about biopsy changes in men who opt for active surveillance, Dr. Porten and colleagues write in their report, published online May 31 in the Journal of Clinical Oncology.

The new study involved 377 men undergoing active surveillance. Ninety-four percent had an initial Gleason score of 6 or less, and 6% had a score of 7 (either 3 + 4 or 4+3).

The mean time to follow-up after the initial biopsy was 54 months. At the first repeat biopsy, 81 men (21%) had an upgraded Gleason score; 91 (24%) had a negative finding, 198 (53%) had no change, and seven men (2%) were downgraded.

Of the 198 with no change after the second biopsy, only 24 were upgraded after a third. Of the 69 men who showed no change until a fourth biopsy, six men then experienced an upgrade. Nearly all the men who had progression on biopsy — 98% — were upgraded to Gleason 3 + 4 disease.

Of the 91 who had a negative second biopsy, 19 (21%) had a positive finding on a third biopsy. Thirteen of 43 (30%) had cancer discovered on a fourth biopsy.

Fifty-nine percent of men with upgraded score opted for definitive treatment, though the authors noted they haven’t been following the men long enough to make definitive statements on treatment outcomes. Still, Dr. Porten suggests that early data indicate there may be little difference between immediate and delayed treatment.

“In individual patients, biopsy changes are fairly variable over time, but overall, men who experience an upgrade and go on to subsequent treatment have favorable outcomes and seem to be no different than those who are treated outright,” Dr. Porten said.

SOURCE: http://bit.ly/liGZW9

J Clin Oncol 2011.

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PR Web Press Release-Old news but fun to see how some marketing folks manipulate the search engines..etc.

The reason this book is number one on Kindle for the subject of prostate cancer is that it is easy to read. The other reason is that there are stories at the end that star the prostate gland. It focuses on the decision-making process, a plan that makes sure that the newly diagnosed prostate cancer patient understands the “voiding consequences” of all of the treatments. It is a starting point, it complements other books, it recommends no treatment, and it tells the prostate journey through the eyes of a urologist who is the patient. It highlights the significance of the wife. Sad humor in parts, fear in others. It’s just an arrow in the ole prostate decision-making quiver. That’s all. It helps the patient define “who they are” because you must know that to make a “customized decision.”

 

If you have to ask how much it costs...you can't afford it

 

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take the pain, burn it as the fuel to overcome adversity

Mushroom Compound Suppresses Prostate Tumours, Australia

23 May 2011

A mushroom used in Asia for its medicinal benefits has been found to be 100 per
cent effective in suppressing prostate tumour development in mice during early
trials, new Queensland University of Technology (QUT) research shows.

The compound, polysaccharopeptide (PSP), which is extracted from the
‘turkey tail’ mushroom, was found to target prostate cancer stem cells and
suppress tumour formation in mice, an article written by senior research fellow
Dr Patrick Ling in the international scientific journal PLoS ONE said.

Dr Ling, from the Australian Prostate Cancer Research Centre-Queensland
and Institute for Biomedical Health & Innovation (IHBI) at QUT, said the
results could be an important step towards fighting a disease that kills 3000
Australian men a year.

“The findings are quite significant,” Dr Ling
said.

“What we wanted to demonstrate was whether that compound could
stop the development of prostate tumours in the first place.

“In the past, other inhibitors tested in research trials have been shown to be up to 70
per cent effective, but we’re seeing 100 per cent of this tumour prevented from
developing with PSP.

“Importantly, we did not see any side effects from
the treatment.”

Dr Ling said conventional therapies were only effective
in targeting certain cancer cells, not cancer stem cells, which initiated cancer
and caused the disease to progress.

During the research trial, which was
done in collaboration with The University of Hong Kong and Provital Pty Ltd,
transgenic mice that developed prostate tumours were fed PSP for 20 weeks.

Dr Ling said no tumours were found in any of the mice fed PSP, whereas
mice not given the treatment developed prostate tumours. He said the research
suggested that PSP treatment could completely inhibit prostate tumour formation.

“Our findings support that PSP may be a potent preventative agent
against prostate cancer, possibly through targeting of the prostate cancer stem
cell population,” he said.

He said PSP had previously shown to possess
anti-cancer properties, and ‘turkey tail’ mushrooms (known as Coriolus
versicolor or Yun-zhi) had been widely used in Asia for medicinal benefits.

However, Dr Ling said it was the first time it had been demonstrated
that PSP had anti-cancer stem cell effects.

Although ‘turkey tail’ mushrooms had valuable health properties, Dr Ling said it would not be possible
to get the same benefit his research showed from simply eating them.

A fundraiser has been organised in September to support further tests for the
therapeutic potential of PSP against prostate tumours either alone or in
combination with other anti-cancer compounds.

Source:
Queensland
University of Technology


Article URL: http://www.medicalnewstoday.com/releases/226143.php

I am in a seventies mood. Just watched a Captain Beefheart documentary on Youtube that was facinating.

I was in high school in the early seventies and was aware of all the “Grateful Dead” stuff going on but was not partaking. I was somewhat “unaware” and afraid to try stuff…then. My oldest brother was the first hippie in Troop County in Georgia. Bellbottoms, long hair, and making pot available to my classmates for a price legitimized him as a hippie. The music I was exposed to at that time was his influence and my next older brother. I remember distinctly a Captain Beefheart album cover (deep red and black coloring, I don’t know which one…very Frank Zappa looking) on the floor in the room of our house closest to the street…the television room. (See author page for picture of my grandmother’s house.) My older brothers were cutting edge music wise. I remember Rushton bringing home one of the first  Allman Brother’s album from the Bryon Music Festival (look at the bands that where there…amazing.) Poco, The Dead, Bowie, Traffic, of course The Beatles, The Kinks, Stones, CSN. were albums they were listening to at the time. I liked Elton John’s Tumbleweed Connection and James Taylor’s Mudslide Slim…my brothers did not quite get my liking that stuff at the time. One of my finest moments was when many years later Rushton said, ” John, I’ve been listening to some Taylor. It’s good…you were on to something back then in high school.”

Now the mushrooms. My brothers and their friends apparently figured out how to make a hallucinogenic mixture out of mushrooms that they called “Mushroom tea, or mushroom koolaid.” As I recall the mushroom they used had a thin blue line making a circle on the under surface of the top of the mushroom. I guess they crushed up the mushroom and then put in koolaid and then drank it. All of this was done under the radar of my mother, grandmother and of course me…I was clueless and of course was not invited or included in any of my older brothers activities. “Where’s John,” they would be asked. Rushton loved to say in reply, ” He’s at an Algebra party.”

You may not remember this “social syndrome” by which a person in high school in an attempt to be included will associate with others in whom he really doesn’t fit. I did it. I asked a girl to a dance who was thought to be one of the wildest students in the school. We were quite the mismatch. I don’t know what I was thinking…well I do… and nothing came of it and I did not benefit from her wildness. But alas…there was this guy who loved my older brothers and wanted to be in their circle. He was rather straight-laced, an athlete ( all my brothers were athletes) and wanted to do stuff with them. Usually it was the benign stuff, i.e. going to get a hamburger, a movie, etc. He was that type of friend for those type of events…not the hard stuff. I know of what I speak…I was that type of friend to others. They’d call me to play tennis or go fishing…but did not call me for parties.

So somehow the ground rules got broken when it came to this particular friend “gettin in with” my brothers in the “mushroom tea” affair. I don’t know where or how but this straight laced guy from a straight-laced family “fell in” with my brothers when they had made and decided to partake of the koolaid. I think they all drank it and they dropped him off at his house either that evening or the next day. That was just the start of it.

“Jennie, what in the world have your boys done to my son?”

My mother was a special person. I never feared, nor did any of us, a spanking or punishment. That was not how she rolled. My relationship and that of my brothers toward her was a sort of unfearful respect. I got in trouble one time in 6th grade and the principal asked me would I like a paddling or for him to call my parents. Well, my parents were my mother. It was a no brainer…”Call my mother.” My mother comes to get me playing the part of the disappointed and strict parent and making all sort of feigned and threatening faces at me and a concerned look to all the principal was saying and why I had to go home for the day.

As we are leaving the school my mother’s demeanor expectantly changed to a soft glowing smile with a smirk. “Where do you want to go eat for lunch Johnny boy?” I knew what I was doing.

My mother is told that the lady’s son has been “crazy” for three days and the last people who saw him normal were “her boys.” After some investigation it came out that he’d been “running” with the McHugh boys and had partaken of the psychogenic elixir they had concocted.

To the best of my knowledge this particular guy never got prostate cancer and neither have any of my brothers.

I never “drank the koolaid” and lo and behold….I got prostate cancer. Go figure, the above study from Australia is right!

As with many psychedelic substances, the effects of psychedelic mushrooms are subjective and can vary considerably among individual users. The mind-altering effects of psilocybin-containing mushrooms typically last anywhere from 3 to 8 hours depending on dosage, preparation method, and personal metabolism. However, the effects can seem to last much longer because of psilocybin’s ability to alter time perception.[13][14]

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we often hate most what we fear

Here’s a dirty little secret for you….prostate cancer patients often don’t choose the treatment that they feel gives them the best chance for cure. They are “I want my cake and eat it too type” patients. By this I mean, “Which treatment will best treat my cancer and limit my potential side effects and complications.” In this way prostate cancer decision-making is much different than in other cancers. Who are you?

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the weakest type of fruit falls easiest to the ground

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